Study Registry
Taking part in a clinical trial can be a good choice but it is often hard to find a clinical trial that is right for you. Many patient organizations and websites maintain lists of clinical trials. The following table lists some of the clinical trials available worldwide. Please note: this is not an exhaustive list, so please check with your local patient organization. Other trials may be available in your country. If you are aware of an open trial that should be listed here, please send us the trial information to: info@sarcoma-patients.org
Soft Tissue Sarcoma Trials
Trial Name
Subtype
Agents
Phase
Status
Sponsor
Metastatic Leiomyosarcoma (LMS)
Lurbinectedin + doxorubicin
IIb/III
Open, recruiting
PharmaMar
Advanced or metastatic Soft Tissue Sarcoma
Onfekafusp alfa (L19TNF) + Doxorubicin vs. Doxorubicin alone
III
Open, recruiting
Philogen S.p.A.
Soft Tissue Sarcoma
M2554
I
Open, recruiting
EMD Serono Research & Development Institute, Inc.
Synovial sarcoma and myxoid/round cell liposarcoma (MRCLS)
DS-2243a
I
Open, recruiting
Daiichi Sankyo
Advanced Pediatric Solid & CNS Tumors
LOXO-292
I/II
Open, recruiting
Loxo Oncology, Inc. (Eli Lilly)
Solid tumors incl. soft tissue sarcomas
AVA6000
I
Open, recruiting
Avacta Life Sciences Ltd.
Advanced solid tumors incl. EHE
IAG933
I
Open, recruiting
Novartis Pharmaceuticals
Epithelioid Sarcoma
Tazemetostat + doxurubicin vs. docurubicin + placebo
III
Open, recruiting
Epizyme Inc.
Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Gene therapy: ADP-A2M
II
Open, recruiting
Adaptimmune
Solid tumors incl. soft tissue and bone sarcomas
TNG462
I/II
Open, recruiting
Tango Therapeutics
Advanced or Metastatic Soft-tissue Sarcoma
Dacarbazine + L19TNF
II
Open, recruiting
Philogen S.p.A.
Extremity Soft Tissue Sarcomas
Preoperative Radiotherapy
II
Open, recruiting
The Netherlands Cancer Center
Solid tumors incl. soft tissue and bone sarcomas
TNG908
I/II
Closed for recruitment
Tango Therapeutics
Bone Sarcoma Trials
Trial Name
Subtype
Agents
Phase
Status
Sponsor
Ewing's sarcoma
Different chemotherapy regimens
II/III
Open, recruiting
University of Birmingham
Conventional chondrosarcoma
Ivosidenib vs. placebo
III
Open, recruiting
Servier Bio-Innovation LLC
Ewing Sarcoma / SDH-deficient GIST
INBRX-109
I
Open, recruiting
INHIBRX Inc.
Ewing's sarcoma, Chondrosarcomas, Osteosarcomas, Chondromas
Regorafenib vs. placebo
II
Open, recruiting (France only)
UNICANCER
Ewing Sarcoma in children/young adults
Lurbinectedin
I/II
Open, recruiting
Jazz Pharmaceuticals
Solid tumors incl. soft tissue and bone sarcomas
TNG462
I/II
Open, recruiting
Tango Therapeutics
Ewing's Sarcoma
Abemaciclib (LY2835219) + Irinotecan + Temozolomide
II
Open, recruiting
Eli Lilly and Company
Ewing Sarcoma / Pediatric Patients
Palbociclib in combination with chemotherapy
II
Closed for recruitment, but active
Pfizer
Solid tumors incl. soft tissue and bone sarcomas
TNG908
I/II
Closed for recruitment
Tango Therapeutics
GIST Trials
Trial Name
Subtype
Agents
Phase
Status
Sponsor
Advanced GIST
CGT9486 (Bezuclastinib) and Sunitinib
III
Closed for recruitment, but active
Cogent Biosciences, Inc.
Advanced GIST
Ripretinib vs. Sunitinib
III
Open, recruiting
Deciphera Pharmaceuticals
Operable GIST
Imatinib
III
Closed for recruitment, but active
Scandinavian Sarcoma Group (SSG)
Desmoid / TGCT Trials
Progressing Desmoid Tumors
AL 102 vs. placebo
II/III
Active, but not recruiting
Ayala Pharmaceuticals, Inc.
Desmoid Tumor/Aggressive Fibromatosis
Nirogacestat
III
Closed for recruitment, but active
SpringWorks Therapeutics, Inc.
Tenosynovial Giant Cell Tumor (TGCT)
Vimseltinib
III
Closed for recruitment, but active
Deciphera Pharmaceuticals LLC
Tenosynovial Giant Cell Tumor
Pimicotinib (ABSK021)
III
Closed for recruitment, but active
Abbisko Therapeutics Co, Ltd
National trial registries
Some of our SPAGN member groups run clinical trial registries to inform about national and international trials in their respective countries.
Browse here to find out more:
- Sarcoma UK
- The Bone Cancer Research Trust, UK
- The German Sarcoma Foundation (Deutsche Sarkom-Stiftung), Germany
- The Sarcoma Foundation of America, USA
- The Chordoma Foundation, USA
- The Desmoid Tumor Research Foundation, USA
- The Life Raft Group (GIST), USA
- Info Sarcomes, France - for Soft Tissue Sarcomas, Bone Sarcomas and GIST
Is your rescource missing on this list? Please let us know and send an email to info@sarcoma-patients.org.